Nadri, Muhammad Helmi and Abu Naser, Mohammed and Zukifli, Razauden Mohamed and Muhamad, Ida Idayu and Ahmad, Farediah and Wan Salleh, Wan Mohd. Nuzul Hakimi and Sirat, Hasnah M. (2015) Antioxidant activity of piper caninum and cyclooxygenase-2 inhibation by methoxlated flavones. African Journal of Traditional Complementary And Altertive Medicines, 12 (2). pp. 120-125. ISSN 1882-0743
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Official URL: http://dx.doi.org/10.4314/ajtcam.v12i2.18
Abstract
Background: This study investigated on antioxidant activity of Piper caninum and cyclooxygenase-2 inhibition by methoxylated flavones. Materials and methods: The present study was carried out to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay respectively. Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations. Conclusion: Based on in vitro and molecular docking, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | piper caninum, antioxidant, cyclooxygenase-2 |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Biosciences and Medical Engineering |
| ID Code: | 57837 |
| Deposited By: | Haliza Zainal |
| Deposited On: | 04 Dec 2016 04:07 |
| Last Modified: | 09 Nov 2021 06:47 |
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