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In vitro degradation and cell viability assessment of Zn-3Mg alloy for biodegradable bone implants

Dambatta, M. S. and Murni, N. S. and Sudin, Izman and Kurniawan, Denni and Froemming, Gabriele R. A. and Hermawan, Hendra (2015) In vitro degradation and cell viability assessment of Zn-3Mg alloy for biodegradable bone implants. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 229 (5). pp. 335-342. ISSN 0954-4119

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Official URL: http://dx.doi.org/10.1177/0954411915584962

Abstract

This article reports the in vitro degradation and cytotoxicity assessment of Zn-3Mg alloy developed for biodegradable bone implants. The alloy was prepared using casting, and its microstructure was composed of Mg2Zn11 intermetallic phase distributed within a Zn-rich matrix. The degradation assessment was done using potentiodynamic polarization and electrochemical impedance spectrometry. The cell viability and the function of normal human osteoblast cells were assessed using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium and alkaline phosphatase extracellular enzyme activity assays. The results showed that the degradation rate of the alloy was slower than those of pure Zn and pure Mg due to the formation of a high polarization resistance oxide film. The alloy was cytocompatible with the normal human osteoblast cells at low concentrations (<0.5 mg/mL), and its alkaline phosphatase activity was superior to pure Mg. This assessment suggests that Zn-3Mg alloy has the potential to be developed as a material for biodegradable bone implants, but the toxicity limit must be carefully observed

Item Type:Article
Uncontrolled Keywords:osteoblast, Zn-Mg alloy
Subjects:T Technology > TJ Mechanical engineering and machinery
Divisions:Mechanical Engineering
ID Code:55811
Deposited By: Fazli Masari
Deposited On:06 Oct 2016 06:06
Last Modified:15 Feb 2017 01:09

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