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1H NMR-based metabolomics investigation of copper-laden rat: a model of Wilson's disease

Jingjing, Xu and Huaizhou, Jiang and Jinquan, Li and Kian, Kai Cheng and Jiyang, Dong and Zhong, Chen (2015) 1H NMR-based metabolomics investigation of copper-laden rat: a model of Wilson's disease. PLoS ONE, 10 (4). ISSN 1932-6203

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Official URL: http://dx.doi.org/10.1371/journal.pone.0119654

Abstract

Wilson's disease (WD), also known as hepatoleticular degeneration (HLD), is a rare autosomal recessive genetic disorder of copper metabolism, which causes copper to accumulate in body tissues. In this study, rats fed with copper-laden diet are used to render the clinical manifestations of WD, and their copper toxicity-induced organ lesions are studied. To investigate metabolic behaviors of 'decoppering' process, penicillamine (PA) was used for treating copper-laden rats as this chelating agent could eliminate excess copper through the urine. To date, there has been limited metabolomics study on WD, while metabolic impacts of copper accumulation and PA administration have yet to be established.

Item Type:Article
Uncontrolled Keywords:Wilson's disease
Subjects:T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:54925
Deposited By: Haliza Zainal
Deposited On:03 Aug 2016 01:52
Last Modified:30 Jul 2017 07:38

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