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Fabrication of BSA loaded poly (Caprolactone) (PCL)/ hydroxyapatite (HA) composite microsphere for tissue engineering application

Rashid, Mad Jin and Sultana, Naznin and Salehhuddin, Hamdan (2014) Fabrication of BSA loaded poly (Caprolactone) (PCL)/ hydroxyapatite (HA) composite microsphere for tissue engineering application. Advanced Materials Research, 1030-1 . pp. 82-85. ISSN 1022-6680

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Official URL: https://dx.doi.org/10.4028/www.scientific.net/AMR....

Abstract

In this study, PCL microsphere has been synthesised using the double emulsion technique and a freeze dry technique. Bovine Serum Albumin (BSA) was added as a model protein and Hydroxyapatite (HA) to enhance osteoconductivity properties of the microsphere. Poly (caprolactone) (PCL)-based microspheres were synthesized and characterized. Microspheres were produced with 5%, 10%, and 15% (w/v) PCL solution (30mL) by dissolving different amounts of PCL in dichloromethane (DCM). Microspheres produced from 5% (w/v) PCL concentration had an average diameter of 100 – 120 μm. Bovine serum albumin (BSA) (0.04% w/v) and 10% w/w of HA powder were added into the microspheres produced from 5% (w/v) PCL concentration. The microsphere was then characterized using different techniques and in vitro release study of BSA was conducted. Prepared microsphere showed good potential for bone tissue engineering.

Item Type:Article
Uncontrolled Keywords:bovine serum albumin(BSA), controlled release delivery, microsphere, tissue engineering
Subjects:Q Science > QA Mathematics > QA76 Computer software
Divisions:Others
ID Code:52846
Deposited By: Siti Nor Hashidah Zakaria
Deposited On:01 Feb 2016 03:53
Last Modified:04 Jul 2018 11:52

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