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Determination of structure of precursor of ibuprofen: purification and analysis

Abdul Jalil, Aishah and Kurono, Nobuhito and Tokuda, Masao (2004) Determination of structure of precursor of ibuprofen: purification and analysis. In: Simposium Kimia Analisis Malaysia Ke-17 (SKAM-17), 24-26 Ogos 2004, Swiss-Garden Resort, Pantai Balok, Kuantan. (Submitted)

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Abstract

(S)-2-(p-isobutylphenyl) propanoic acid, so called ibuprofen, is one of the most popular anti-inflammatory agents. An efficient cross-coupling reaction of organozinc compound of ethyl 2-bromoacrylate, prepared by the reaction of hightly reactive zinc was carried out with aryl iodide to synthesize 2-(4-isobutylphenyl)-propenoate, a precursor of ibuprofen. Highly reactive zinc metal (EGZn/Naph) was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. The synthesized precursor of ibuprofen was purified by thin layer chromatography on silica gel and its structure was confirmed by elemental analysis, mass, IR, 1H NMR and 13C NMR spectroscopic analysis.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:Ibuprofen, oganozinc compound, reactive zinc, thin layer chromatography
Subjects:T Technology > T Technology (General)
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:5240
Deposited By: Norhani Jusoh
Deposited On:06 Mar 2008 10:24
Last Modified:01 Jun 2010 15:27

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