Universiti Teknologi Malaysia Institutional Repository

Synthesis of precursor of anti-cancer drugs

Abdul Jalil, Aishah and Kurono, Nobuhito and Tokuda, Masao (2004) Synthesis of precursor of anti-cancer drugs. In: Annual Fundamental Science Seminar 2004 (AFSS 2004), 14-15 June 2004, Ibnu Sina Institute for Fundamental Science Studies, UTM. (Submitted)

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Abstract

Highly reactive electrogenerated zinc metal (EGZn/Naph) was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This reactive zinc was used for efficient transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which was reacted with various aryl halides in the presence of palladium catalyst to give the corresponding cross-coupling products, ethyl 2-arylpropenoates, in high yields. These cross-coupling reactions were successfully applied to a synthesis of the precursors of non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen and ioxoprofen, which recently, have been shown to decrease the risk of cancer.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:Alkylbromide, cross-coupling, electrolysis, palladium catalyst, reactive zinc
Subjects:T Technology > T Technology (General)
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:5235
Deposited By: Norhani Jusoh
Deposited On:06 Mar 2008 03:44
Last Modified:01 Jun 2010 15:27

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