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Efficient cross-coupling reaction of functionalized alkyl bromides with aryl halides by using electrochemical method

Abdul Jalil, Aishah and Kurono, Nobuhito and Takasugi, Shingo and Tokuda, Masao (2004) Efficient cross-coupling reaction of functionalized alkyl bromides with aryl halides by using electrochemical method. In: Annual Fundamental Science Seminar 2004 (AFSS 2004), 14-15 June 2004, Ibnu Sina Institute for Fundamental Science Studies, UTM. (Submitted)

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Abstract

Highly reactive zinc metal was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This reactive zinc (EGZn/Naph) was used for transformation of bromoalkanes into the corresponding organozinc bromides, which can not be achieved by the use of usual zinc metals. Reaction of the organozinc compounds thus prepared with various aryl iodides in the presence of 5 mol% of palladium catalyst gave the corresponding cross-coupling products in hick yields. Arylzinc iodides were also prepared by the use of EGZn/Naph and they were reacted with other aryl iodides to give the corresponding cross-coupled biaryl in good yields.

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:Alkylbromide, cross-coupling, electrolysis, palladium catalysts, reactive zinc
Subjects:T Technology > T Technology (General)
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:5234
Deposited By: Norhani Jusoh
Deposited On:06 Mar 2008 03:42
Last Modified:01 Jun 2010 15:27

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