Mohd. Sirat, Hasnah and Muhammad, Aminu (2013) Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae). EXCLI Journal, 12 . pp. 824-830. ISSN 1611-2156
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Abstract
Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34% at 100 μM (IC50 0.46 μM) compared to the positive control, indomethacin (79.20%, IC50 0.24 μM)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Bauhinia rufescens, COX-2, phytochemicals |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Science |
| ID Code: | 49079 |
| Deposited By: | Siti Nor Hashidah Zakaria |
| Deposited On: | 02 Dec 2015 02:08 |
| Last Modified: | 27 Sep 2018 04:07 |
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