Shamsir, Mohd Shahir and Dalby, Andrew (2007) Î²-sheet containment by flanking prolines: Molecular Dynamic Simulations of the inhibition of Î²-sheet elongation by proline residues in human prion protein. Biophysical Journal, 92 . pp. 2080-2089.
Official URL: http://www.biophysj.org/cgi/content/abstract/92/6/...
Previous molecular dynamic simulations have reported elongation of the existing Î²-sheet in prion proteins. Detailed examination has shown that these elongations do not extend beyond the proline residues flanking these Î²-sheets. In addition, proline has also been suggested to possess a possible structural role in preserving protein interaction sites by preventing invasion of neighbouring secondary structures. In this paper, we have studied the possible structural role of the flanling proline residues by simulating mutant structures with alternate substitution of the proline residues with valine. Simulations showed a directional inhibition of elongation with the elongation progressing in the direction of valine including evident inhibition of elongation by existing proline residues. This suggests that the flanking proline residues in prion proteins may have a containment role and would confine the Î²-sheet within a specific length.
|Uncontrolled Keywords:||Molecular dynamics simulation, prion, proline, beta sheet|
|Subjects:||Q Science > Q Science (General)|
Q Science > QH Natural history > QH301 Biology
|Deposited By:||Mr Mohd Shahir Shamsir|
|Deposited On:||16 Feb 2007 03:30|
|Last Modified:||01 Jun 2010 02:44|
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