Abdelwahab, Siddig Ibrahim and Ahmed Hassan, Loiy Elsir and Mohd. Sirat, Hasnah and Ahmed Yagi, Sakina M. and Koko, Waleed S. and Mohan, Syam and Taha, Manal Mohamed Elhassan and Ahmad, Syahida and Cheah, Shiau Chuen and Narrima, Putri and Rais, Mohd. Mustafa and A. Hadi, A. Hamid (2011) Anti-inflammatory activities of cucurbitacin E isolated from citrullus latus var. citroides: role of reactive nitrogen species and cyclooxygese enzyme inhibition. Fitoterapia, 82 . pp. 1190-1197. ISSN 0367-326X
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Abstract
The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-? increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenaninduced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | reactive nitrogen species |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Science |
| ID Code: | 44741 |
| Deposited By: | Haliza Zainal |
| Deposited On: | 21 Apr 2015 03:31 |
| Last Modified: | 30 Aug 2017 07:17 |
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