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Enantiomer separation by enantioselective inclusion complexation-organic solvent nanofiltration

Ghazali, Nazlee Faisal and Ferreira, Frederico and Livingston, Andrew (2006) Enantiomer separation by enantioselective inclusion complexation-organic solvent nanofiltration. Tetrahedron: Asymmetry, 17 (2). pp. 1846-1852. ISSN 0957-4166

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Official URL: http://dx.doi.org/10.1016/j.tetasy.2006.06.026

Abstract

A novel chiral separation process, which utilizes a combination of enantioselective inclusion complexation (EIC) and organic solvent nanofiltration (OSN), was developed. Although EIC is an attractive way to resolve racemates, the difficulties associated with enantiomer recovery and chiral host recycle has limited large-scale applications. EIC coupled with OSN replaces distillation for the recovery of enantiomers from enantioenriched solid complex. A decomplexation solvent is employed to dissociate enantiomers from the complex, and subsequent separation of enantiomers from the chiral host is realized using OSN. The new process was investigated using racemic 1-phenylethanol as the guest and (R,R)-TADDOL as the chiral host. This novel technology expands the application of EIC to the resolution of nonvolatile racemates

Item Type:Article
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:419
Deposited By: Mohd Nazlee Faisal
Deposited On:16 Feb 2007 02:31
Last Modified:21 Oct 2010 07:39

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