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Gastric protection ability of some medicinal Malaysian plants against ethanol induction model in sprague dawley rats

Wasman, Suhailah and Ameen, Mahmood and Lee, Suan Chua and Hamdan, Salehhuddin (2012) Gastric protection ability of some medicinal Malaysian plants against ethanol induction model in sprague dawley rats. Jurnal Teknologi, 57 (1). pp. 199-209. ISSN 0127-9696

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Abstract

Ethanol extracts of different traditional Malaysian plants (Polygonum minus, Andrographis paniculata, Curcuma xanthorrhiza,Momordica charantia and Strobilanthes crispus) were evaluated for their gastroprotective activities. In this experiment several groups of Sprague Dawley rats weighing 200–250gm were used. The first group was pre treated with (0.25% w/v) carboxymethyl cellulose (negative control, 5 ml/kg), the second group was pre treated with 20 mg/kg omeprazole (positive control) and the other groups were pretreated with the selected Malaysian medicinal plants in two different doses 250 and 500 mg/kg respectively. After 60 min all the rats were treated with 95% ethanol for ulcer induction. Rats were sacrificed 1 h after induction and the stomachs were analyzed for gross and histological changes. Negative control group showed extensive lesions of gastric mucosal layer, whereas rats pretreated with omeprazole and Malaysian plants showed significant and dose dependent reduction in gastric lesions. Amongst, the selected plants Polygonum minuspotentially promote better inhibition percentage of ulcer area. So that we can conclude that Polygonum minus could be the selective plant as an antiulcerogenic agent for the treatment of gastric ulcer.

Item Type:Article
Uncontrolled Keywords:Ulcer prevention, Malaysian medicinal plant, gross lesion, histopathology
Subjects:Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
Divisions:Biosciences and Bioengineering
ID Code:32674
Deposited By: Fazli Masari
Deposited On:17 Jun 2013 04:51
Last Modified:14 Oct 2018 07:23

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