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Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding

Jantan, Ibrahim and Pisar, Mazura and Mohd. Sirat, Hasnah and Basar, Norazah and Jamil, Shajarahtunnur and Mat Ali, Rasadah and Jalil, Juriyati (2004) Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding. Phytotherapy Research , 18 (12). pp. 1005-1007. ISSN 0951-418X

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Official URL: http://dx.doi.org/10.1002/ptr.1608

Abstract

Ten compounds isolated from Alpinia mutica Roxb., Curcuma xanthorrhiza Roxb. and Kaempferia rotunda Linn. (Family: Zingiberaceae) were investigated for their platelet-activating factor (PAF) antagonistic activities on rabbit platelets using 3H-PAF as a ligand. Among them, four compounds showed significant inhibitory effects. Alpinetin and 5,6-dehydrokawain isolated from A. mutica exhibited IC50 values of 41.6 and 59.3 µm, respectively. The IC50 values of 3-deacetylcrotepoxide and 2-hydroxy-4,4,6-trimethoxychalcone from K. rotunda were 45.6 and 57.4 µM, respectively. 1-Methoxy-2-methyl-5-(1,5-dimethylhex-4-enyl)-benzene, synthesized by methylation of xanthorrhizol which was obtained from C. xanthorrhiza, showed an IC50 value of 40.9 µm. The results indicated that these compounds were relatively strong PAF receptor binding inhibitors

Item Type:Article
Uncontrolled Keywords:platelet-activating factor (PAF), antagonistic activities, zingiberaceae, alpinia mutica, kaempferia rotunda, curcuma
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:2926
Deposited By: Ms Zalinda Shuratman
Deposited On:18 May 2007 02:19
Last Modified:29 Mar 2011 04:00

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