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Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L.

Deny Susanti, Deny Susanti and Mohd. Sirat, Hasnah and Ahmad, Farediah and Mat Ali, Rasadah and Aimi, Norio and Kitajima, Mariko (2007) Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L. Food Chemistry, 103 (3). pp. 710-716. ISSN 0308-8146

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Phytochemical and bioactivity studies of the flowers of Melastoma malabathricum L. (Melastomataceae) have been carried out. The ethyl acetate extract yielded three compounds, identified as naringenin, kaempferol and kaempferol-3-O-d-glucoside, and methanol extract gave kaempferol-3-O-(2",6"-di-O-p-trans-coumaroyl)glucoside and kaempferol-3-O-d-glucoside. The crude extracts and isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant assay was carried out by the DPPH radical-scavenging electron spin resonance (ESR) spectroscopic method. The cytotoxicity was measured by the MTT assay against a MCF7 cell line. Naringenin, kaempferol, kaempferol-3-O-d-glucoside, kaempferol-3-O-(2",6"-di-O-p-trans-coumaroyl) glucoside, ethyl acetate and methanol extracts were found to be active as radical-scavengers with IC50 values of 0.52 mM, 81.5 µM, 1.07 mM, 35.8 µM, 7.21 µg/ml and 6.59 µg/ml, respectively. Naringenin and kaempferol-3-O-(2",6"-di-O-p-trans-coumaroyl)glucoside were also found to be active in inhibiting cell proliferation of MCF7 with IC50 values of 0.28 µM and 1.3 µM, respectively

Item Type:Article
Uncontrolled Keywords:Melastoma malabathricum; Melastomataceae; Flavonoids; Antioxidant; Cytotoxic
Subjects:Q Science > QD Chemistry
ID Code:2902
Deposited By: Ms Zalinda Shuratman
Deposited On:18 May 2007 02:18
Last Modified:01 Jun 2010 03:05

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