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Antimicrobial and anti-inflammatory activities of piper porphyrophyllum (Fam. Piperaceae)

Ahmad, Farediah and Emrizal, Emrizal and Mohd. Sirat, Hasnah and Jamaludin, F. and Mustapha, N. M. and Ali, R. M. and Arbain, D. and Aboul, Enei (2011) Antimicrobial and anti-inflammatory activities of piper porphyrophyllum (Fam. Piperaceae). Arabian Journal of Chemistry . pp. 1-3. ISSN 1878-5352

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Official URL: http://dx.doi.org/10.1016/j.arabjc.2010.12.032

Abstract

The crude extracts and isolated compounds of Piper porphyrophyllum (Piperaceae) were evaluated for antibacterial and anti-inflammatory activities. The ethyl acetate extract and 3',4',5,7-tetramethoxyflavone exhibited the highest activity against Staphylococcus aureus giving values of MIC = 62.5 and 250 µg/mL, respectively. 5-Hydroxy-7-methoxyflavanone and 4',5-dihydroxy-3',7-dimethoxyflavone were active against Pseudomonas aeruginosa, both with MIC value 125 µg/mL. The hexane extract and 4',5-dihydroxy-3',7-dimethoxyflavone gave the highest anti-inflammatory activity in in vitro quantitative lipoxygenase inhibition assay with inhibitory activity of (IE) 99.72% and 91.81%, respectively.

Item Type:Article
Uncontrolled Keywords:piper porphyrophyllum, extracts, flavonoids, antibacterial, anti-inflammatory
Subjects:Q Science
Divisions:Science
ID Code:28786
Deposited By: Liza Porijo
Deposited On:23 Nov 2012 08:03
Last Modified:21 Sep 2014 05:15

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