Abdelwahab, S. I. and Hassan, L. E. A. and Mohd. Sirat, Hasnah and Yagi, S. M. A. and Koko, W. S. and Mohan, S. and Taha, M. M. E. and Ahmad, S. and Chuen, C. S. and Narrima, P. and Rais, M. M. and Hadi, A. H. A. (2011) Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia, 82 (8). pp. 1190-1197. ISSN 0367-326X
Official URL: http://dx.doi.org/10.1016/j.fitote.2011.08.002
The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-? increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS.
|Uncontrolled Keywords:||cucurbitacin E, cyclooxygenase enzymes: reactive nitrogen species, RAW 264.7 macrophage, wild melon|
|Deposited By:||Liza Porijo|
|Deposited On:||23 Nov 2012 07:50|
|Last Modified:||21 Sep 2014 05:09|
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