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Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition

Abdelwahab, S. I. and Hassan, L. E. A. and Mohd. Sirat, Hasnah and Yagi, S. M. A. and Koko, W. S. and Mohan, S. and Taha, M. M. E. and Ahmad, S. and Chuen, C. S. and Narrima, P. and Rais, M. M. and Hadi, A. H. A. (2011) Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia, 82 (8). pp. 1190-1197. ISSN 0367-326X

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Official URL: http://dx.doi.org/10.1016/j.fitote.2011.08.002

Abstract

The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-? increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS.

Item Type:Article
Uncontrolled Keywords:cucurbitacin E, cyclooxygenase enzymes: reactive nitrogen species, RAW 264.7 macrophage, wild melon
Subjects:Q Science
Divisions:Science
ID Code:28785
Deposited By: Liza Porijo
Deposited On:23 Nov 2012 07:50
Last Modified:21 Sep 2014 05:09

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