Abdelwahab, Siddig Ibrahim and Hassan, Loiy Elsir Ahmed and Mohd. Sirat, Hasnah and Yagi, Sakina M. Ahmed and Koko, Waleed Syaed and Mohan, Syam Morali and Taha, Manal Mohamed Elhassan and Ahmad, Syahida and Cheah, Shiau Chuen and Narrima, Putri and Rais, Mohd. Mustafa and Abdul Hadi, Abdul Hamid (2011) Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition. Fitoterapia, 82 (8). pp. 1190-1197. ISSN 0367-326X
Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.fitote.2011.08.002
Abstract
The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-? increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cucurbitacin E, cyclooxygenase enzymes: reactive nitrogen species, RAW 264.7 macrophage, wild melon |
| Subjects: | Q Science |
| Divisions: | Science |
| ID Code: | 28785 |
| Deposited By: | Yanti Mohd Shah |
| Deposited On: | 23 Nov 2012 07:50 |
| Last Modified: | 28 Jan 2019 03:38 |
Repository Staff Only: item control page
