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Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.)

Atiax, E. and Ahmad, Farediah and Mohd. Sirat, Hasnah and Arbain, D. (2011) Antibacterial activity and cytotoxicity screening of sumatran kaduk (Piper sarmentosum Roxb.). Iranian Journal of Pharmacology and Therapeutics, 10 (1). pp. 1-5. ISSN 1735-2657

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Abstract

Phytochemical investigation of piper sarmentosum roxb., yielded four compunds; three amides, identified as 3-(3'.4'5'-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4'-methoxyphenylpropanoyl) pyrrole, N-(3-phenylpropanoyl) pyrrole and a sterol namely B-sitostrel. 3-(4'-Methoxyphenylpropanoyl) pyrrole was found for the first time in this piper species. All chemical constituents were tested foe their antibacterial activity using disk diffusion method and cytotoxicity screening using sul-forhodamine B (SRB) assay. All of the compounds were found only active towards gram-positive bacteria except 3-(4'-methoxyphenylpropanoyl) pyrrole with no activity against both gram-positive and gram-negative bacteria. Meanwhile, the cytotoxicity screening using SRB assay indicated that none of these compounds was active as an anticancer agent.

Item Type:Article
Uncontrolled Keywords:piperaceae, p. sarmentosum, amides, antibacterial, cytotoxicity
Subjects:Q Science
Divisions:Science
ID Code:28784
Deposited By: Liza Porijo
Deposited On:23 Nov 2012 07:26
Last Modified:23 Nov 2012 07:26

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