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Labisia pumila extract protects skin cells from photoaging caused by UVB irradiation

Sarmidi, Mohamad Roji and Choi, Hyun-kyung and Kim, Dong-hyun and Kim, Jin Wook and Ngadiran, Sulaiman and Seo Park, Chang (2010) Labisia pumila extract protects skin cells from photoaging caused by UVB irradiation. Journal of Bioscience and Bioengineering, 109 (3). 291 - 296. ISSN 1389-1723

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Official URL: http://dx.doi.org/10.1016/j.jbiosc.2009.08.478

Abstract

Labisia pumila (Myrsinaceae), known as "Kacip Fatimah," has been used by many generations of Malay women to induce and facilitate child birth as well as a post partum medicine. However, its topical application on skin has not been reported yet. In this study, we have focused on the anti-photoaging effects of L. pumila. Extract of L. pumila was first analyzed for their antioxidant activities using DPPH (2,2-diphenyl-1-picrylhydrazyl) since UV irradiation is a primary cause of reactive oxygen species (ROS) generation in the skin. The 50% free radical scavenging activity (FSC(50)) of L. pumila extract was determined to be 0.006%, which was equal to that produced by 156 microM ascorbic acid. TNF-alpha and cyclooxygenase (COX-2) play a primary role in the inflammation process upon UV irradiation and are known to be stimulated by UVB. Treatment with L. pumila extract markedly inhibited the TNF-alpha production and the expression of COX-2. Decreased collagen synthesis of human fibroblasts by UVB was restored back to normal level after treatment with L. pumila extract. On the other hand, the enhanced MMP-1 expression upon UVB irradiation was down regulated by L. pumila extract in a dose-dependent manner. Furthermore, treatment of normal keratinocytes with L. pumila extract attenuated UVB-induced MMP-9 expression. These results collectively suggest L. pumila extract has tremendous potential as an anti-photoaging cosmetic ingredient.

Item Type:Article
Uncontrolled Keywords:labisia pumila, photoaging, TNF-a, COX-2, collagen, MMP-1
Subjects:Q Science > QD Chemistry
Divisions:Chemical Engineering
ID Code:26267
Deposited By: Liza Porijo
Deposited On:29 Jun 2012 03:36
Last Modified:20 Jul 2012 07:53

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