Abd. Majid, Fadzilah Adibah and S. A. S. H., Ajlia and A., Suvik and M. A. W., Effendy and H., Serati Nouri (2010) Efficacy of papain-based wound cleanser in promoting wound regeneration. Pakistan Journal of Biological Sciences, 13 (12). 596 -603. ISSN 1028-8880
Official URL: http://scialert.net/abstract/?doi=pjbs.2010.596.60...
A new invention, papain-based wound cleanser is formulated by incorporating papain, a proteolytic enzyme extracted from Carica papaya into the formulation. This cleanser is invented to simplify the methods in wound management by combining wound cleansing and wound debridement using a single formulation. This study describes the preparation and preclinical study of papain-based wound cleanser in accelerating wound healing. In this study, papain-based wound cleanser was used to treat wound incision on Sprague-Dawley rats while distilled water and Betadine® were used as negative and positive control. Twenty-seven clinically healthy white rats were randomly divided into three groups and treated accordingly until the 21st day post-incision. Wound reduction rates and histological analysis were obtained to asses the healing pattern. Rats treated with papain-based wound cleanser showed a progressive wound healing based on the wound reduction rates and histological analysis when compared with rats treated with distilled water and Betadine®. Better collagen deposition and presence of skin organelles in rats treated with papain-based wound cleanser demonstrated its efficacy in promoting wound healing. In addition to its wound healing effect, papain-based wound cleanser is also integrated with antibacterial properties which make it a complete package for wound management. However, further studies should be carried out to ensure its safety for human usage.
|Uncontrolled Keywords:||papain, wound cleanser, regeneration, wound healing|
|Subjects:||Q Science > QH Natural history > QH301 Biology|
|Deposited By:||Liza Porijo|
|Deposited On:||28 Jun 2012 00:38|
|Last Modified:||24 Aug 2014 09:17|
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