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Chiral resolution of secondary alcohol using immobilized lipases in organic media

Sarmidi, Mohamad Roji and Chua, Lee Suan (2006) Chiral resolution of secondary alcohol using immobilized lipases in organic media. In: Special Topics In Bioprocess Engineering Volume I. Penerbit UTM, Johor , pp. 65-103. ISBN 978-983-52-0600-9

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Official URL: http://www.penerbit.utm.my/bookchapterdoc/FKKKSA/b...


The development of chirotechnology is currently getting much attention, especially from pharmaceutical and fine chemical industries. This ever-increasing trend of utilizing enzyme chirality in biotransformation is mainly due to the stability and selectivity of enzymes [1-2]. Enzymes, especially lipases are relatively stable in organic media. Although the idea of enzyme working in nonaqueous system media goes against the conventional practice, the reaction schemes have been confirmed by several researches over the past few years [2-6]. Furthermore, the performance of lipases is much better in organic solvents than in aqueous media [7]. Many organic substances such as fatty acids and lipids are also well dissolved in organic solvents. The reactions involving these organic substances are difficult to carry out in aqueous media.

Item Type:Book Section
Subjects:Q Science > QD Chemistry
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:25640
Deposited By: Mrs Liza Porijo
Deposited On:23 May 2012 07:35
Last Modified:05 Feb 2017 03:46

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