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Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography

Wan Ibrahim, Wan Aini and Abd. Wahib, Siti Munirah and Hermawan, Dadan and Sanagi, Mohd. Marsin and Aboul-Enein, Hassan Y. (2012) Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography. Chirality, 24 (3). pp. 252-4. ISSN 1520-636X

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Official URL: http://dx.doi.org/10.1002/chir.21990

Abstract

A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-β-CD (HP-β-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-β-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation temperature and separation voltage of 25°C and 25 kV, respectively. To the author's best knowledge, this is the first CD-MEKC study able to successfully separate the four stereoisomer of vinpocetine in separation time of 9.5 min and resolution of 1.04-3.87. Chirality, 2012. © 2012 Wiley Periodicals, Inc.

Item Type:Article
Uncontrolled Keywords:enantioseparation,vinpocetine,cyclodextrins,cyclodextrin-modified micellar electrokinetic chromatography,capillary electrophoresis
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:23019
Deposited By: Kamariah Mohamed Jong
Deposited On:09 Mar 2012 01:41
Last Modified:13 Mar 2012 03:43

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