Wan Ibrahim, Wan Aini and Abd. Wahib, Siti Munirah and Hermawan, Dadan and Sanagi, Mohd. Marsin and Aboul-Enein, Hassan Y. (2012) Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography. Chirality, 24 (3). pp. 252-4. ISSN 1520-636X
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Official URL: http://dx.doi.org/10.1002/chir.21990
Abstract
A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-β-CD (HP-β-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-β-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation temperature and separation voltage of 25°C and 25 kV, respectively. To the author's best knowledge, this is the first CD-MEKC study able to successfully separate the four stereoisomer of vinpocetine in separation time of 9.5 min and resolution of 1.04-3.87. Chirality, 2012. © 2012 Wiley Periodicals, Inc.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Science |
| ID Code: | 23019 |
| Deposited By: | Kamariah Mohamed Jong |
| Deposited On: | 09 Mar 2012 01:41 |
| Last Modified: | 17 Oct 2017 02:52 |
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