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Depigmentation activity of curcuma xanthorrhiza and zingiber zerumbet

Ujang, Zanariah and Nordin, Nurul Izza and Mohd Diah, Mazita and Mohd Helan, Mohd Helme and Abdul Rahman, Rozanida and Abdul Rashid, Ahmad Hazri and Mohd Sirat, Hasnah (2004) Depigmentation activity of curcuma xanthorrhiza and zingiber zerumbet. In: The 21st Annual Seminar of the Malaysian Natural Product Society.(Herbal Medicine:Natural Products Society), 25 Nov. 2004, Palm Garden, Putrajaya Malaysia..

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Abstract

Curcuma xanthorrhiza (locally known as temulawak) and Zingiber zerumbet (local name lempoyang) are two perennial rhizomatous herbs belonging to the plant family Zingiberaceae. Both of the species are aromatic and contain high amounts of essential oils. The main phytochemical in the sesquiterpenoids fraction of Curcuma xanthorrhiza is xanthorrhizol while the major constituent of Zingiber zerumbet is zerumbone. In this work, extracts of Curcuma xanthorrhiza and Zingiber zerumbet were prepared by various types of extraction method such as water, solvent and supercritical fluid extraction. The extracts and major phytochemical constituents were investigated for their depigmentation activity by using the tyrosinase inhibition assay. The enzyme tyrosinase is responsible for the production of melanin, the pigment that gives color to hair and skin and provides protection against UV rays. Based on the results of the tyrosinase inhibition study, it was found that the extracts of Curcuma xanthorrhiza and Zingiber zerumbet interact synergistically to strongly inhibit tyrosinase activity. Xanthorrhizol and zerumbone, the sesquiterpene isolated from Curcuma xanthorrhiza and Zingiber zerumbet respectively displayed higher depigmentation activity compared to the total extracts. The most economical extract, prepared from solvent extraction was further investigated for its depigmentation effect. The extract was incorporated into topical formulations and in vitro and in vivo studies were carried out to determine the ability of the extract to inhibit melanin synthesis. The cytotoxic effect of the extracts towards melanocytes, the skin cells that produce melanin was also conducted using the neutral red uptake method. , , , &

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:Depigmentation, tyrosinase inhibition, melanin synthesis, Zingiber zerumbet, Curcuma xanthorrhiza
Subjects:Faculty / Division > Science
Q Science > QD Chemistry
ID Code:20607
Deposited By: Mrs Liza Porijo
Deposited On:28 Aug 2017 14:04
Last Modified:29 Aug 2017 02:57

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