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The effect of alcohol on the performance of lipase-immobilized enzymatic membrane reactor for esterification of (R,S)-ketoprofen

Ong, Ai Lien and Chuan Fu, Kian and Harun @ Kamaruddin, Azlina and Bhatia, Subhash (2006) The effect of alcohol on the performance of lipase-immobilized enzymatic membrane reactor for esterification of (R,S)-ketoprofen. In: 1st International Conference on Natural Resources Engineering & Technology 2006, 24-25th July 2006, Putrajaya, Malaysia.

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Abstract

The effect of alcohols on the performance of lipase-immobilized enzymatic membrane reactor (EMR) for enantioselective esterification of (R,S)-ketoprofen has been studied. In this work, mixed solvent medium was used and the (R)-ketoprofen was reacted with the different alcohols in the presence of immobilized lipase B from Candida antartica, leaving the target product (S)-ketoprofen in its unreacted form. The alcohols involved in the reactions were ethanol, butanol, heptanol and 2-ethoxyethanol. The chain length of alcohol was found to significantly affect the performance of the esterification in EMR. Through the alcohols screening, the esterification reaction using ethanol in EMR showed higher initial rate, conversion, enzyme enantioselectivity, enantiomeric excess of substrate (ees) and enantiomeric excess of product (eep). However the results with butanol showed less inhibition effect on a wider range of temperature

Item Type:Conference or Workshop Item (Paper)
Uncontrolled Keywords:Effect of alcohol; enzymatic membrane reactor, candida antarctica lipase B; ketoprofen; esterification
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:190
Deposited By: Cik Rasyidah Mohd Daud
Deposited On:15 Feb 2007 11:16
Last Modified:01 Jun 2010 02:41

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