Jully, Tan and Foo Chwan Yee, Dominic and Kumaresan, sivakumar and Abdul Aziz, Ramlan (2008) Computer-aided process design tools for debottlenecking a batch pharmaceutical production. The Journal of The Institution of Engineers, Malaysia, 69 (4). 30 - 37. ISSN 0126-513X
Official URL: http://dspace.unimap.edu.my/dspace/bitstream/12345...
The main objective of this work is to model and to debottleneck a batch pharmaceutical production with computer-aided process design (CAPD) and simulation tools. An eye drop production case study is firstly modelled based on a pharmaceutical production plant. Throughput analysis is next utilised to identify process bottlenecks that limit the increase of production and to evaluate different debottlenecking schemes. Scheme 1 considers an effort to maximise process throughput for a single batch operation, while Schemes 2 and 3 explore the possibility of minimising combined utilisation value of the process bottleneck. With the increase of batch throughput, installation of a new labelling process and the addition of an intermediate tank, Scheme 3 is identified as the debottlenecking scheme that achieves the increased production demand of 25%.
|Divisions:||Chemical and Natural Resources Engineering (Formerly known)|
|Deposited By:||Kamariah Mohamed Jong|
|Deposited On:||15 Feb 2017 07:09|
|Last Modified:||15 Feb 2017 07:12|
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