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Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient

Zainal Alam, Muhd. Nazrul Hisham and Razali, Firdausi (2005) Scale-Up Of Stirred And Aerated BioengineeringTM Bioreactor Based On Constant Mass Transfer Coefficient. Jurnal Teknologi F (43F). pp. 95-110. ISSN 0127-9696

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Official URL: http://www.penerbit.utm.my/cgi-bin/jurnal/artikel....

Abstract

The Scale-Up Studies Based On The Constant Oxygen Transfer Coefficient, Kla From 16 L To 150 L Of Aerated And Agitated Bioreactor Were Performed. By Employing The Static Gassing Out Techniques, The Kla Values Were Calculated At Different Sets Of Impeller Speeds And Air Flow Rates Performed In Various Viscosities And Temperatures In The 16 L And 150 L Bioengineeringtm Stirred Bioreactor. Empirical Correlation Was Employed To Correlate And Investigate The Dependence Of Kla On Specific Power Input And Superficial Air Velocity. In Maintaining A Constant Kla Upon Scale-Up From 16 L To 150 L, The Specific Power Input And The Superficial Air Velocity Cannot Be Maintained, Thus An Adjustment Has To Be Done. From The Experimental Results At 150 L, It Was Discovered That The Specific Power Input From 0.0001 To 4.2 Kw/M3 And Superficial Air Velocity Within The Range Of 9 × 10-4 M/S To 7 × 10-3 M/S Employed Gave A Comparable Kla Values Achieved At 16 L Scale. Hence, The Calculated Scaling-Up Factor For Impeller Speed And Air Flow Rate Were 0.28 And 3.1, Respectively. The Comparable Results Obtained From Both Scales Confirmed That The Scale-Up Protocol Developed Works.

Item Type:Article
Uncontrolled Keywords:Oxygen Transfer, Empirical Relationship, Stirred Bioreactor, Scale-Up
Subjects:Q Science > Q Science (General)
T Technology > T Technology (General)
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:1698
Deposited By: En Mohd. Nazir Md. Basri
Deposited On:19 Mar 2007 06:56
Last Modified:07 Nov 2010 05:43

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