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Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems

Chen, Yong and Mat, Hanapi and Xu, Zhinan and Jin, Zhihua and Cen, Peilin (2004) Determination of teicoplanin A2's partition coefficient in different liquid-liquid extraction systems. Chinese Journal of Chemical Engineering, 12 (4). pp. 493-497. ISSN 1004-9541

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Abstract

Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent systems were studied: conventional extraction, reactive extraction and reverse micelle extraction. With conventional solvent extraction, n-butanol demonstrated high partition coefficient for teicoplanin, but low extraction ratio because of its high solubility in water. Reactive extraction of teicoplanin showed the highest partition coefficient with almost 100% recovery in organic phase when tri-n-octylmethyl ammonium chloride (TOMAC) was used as extractant and pH value was above 5.0. A reverse micelle system, consisted of isooctane +10 mmol·L-1 TOMAC +1% n-octanol, also offered high separation factor for teicoplanin. The results are beneficial for the design of teicoplanin separation and purification process.

Item Type:Article
Uncontrolled Keywords:conventional extraction, partition coefficients, reverse micelle extraction, teicoplanin
Subjects:Q Science > QD Chemistry
T Technology > TP Chemical technology
Divisions:Chemical Engineering
ID Code:15926
Deposited By: Ms Zalinda Shuratman
Deposited On:31 Oct 2011 14:42
Last Modified:31 Oct 2011 14:42

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