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Stacking and sweeping in cyclodextrin-modified MEKC for chiral separation of hexaconazole, penconazole and myclobutanil

Wan Ibrahim, Wan Aini and Hermawan, Dadan and Sanagi, M. Marsin and Aboul-Enein, Hassan Y. (2010) Stacking and sweeping in cyclodextrin-modified MEKC for chiral separation of hexaconazole, penconazole and myclobutanil. Chromatographia, 71 (3-4). pp. 305-309. ISSN 0009-5893

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Official URL: http://dx.doi.org/10.1365/s10337-009-1427-y

Abstract

A CD-MEKC method for the on-line preconcentration and chiral separation of three chiral triazole fungicides, namely hexaconazole, penconazole and myclobutanil is reported. Simultaneous enantioseparation of the three triazole fungicides was successfully achieved by the CD-MEKC system containing 40 mM HP-?-CD + 50 mM SDS in 25 mM phosphate buffer (pH 3.0) solution. Stacking with a reverse migrating micelle (SRMM) and sweeping were then used in this study as two on-line preconcentration methods to enhance the concentration sensitivity. The results indicate that sweeping-CD-MEKC is superior to SRMM-CD-MEKC in terms of the sensitivity enhancement factor (SEF) of the three triazole fungicides ranging from 62- to 67-fold. This is the first report on the chiral separation of hexaconazole, penconazole and myclobutanil by SRMM-CD-MEKC and sweeping-CD-MEKC methods.

Item Type:Article
Uncontrolled Keywords:chiral separation, micellar electrokinetic chromatography, stacking-cd-mekc, sweeping-cd-mekc, triazole fungicides
Subjects:Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions:Science
ID Code:13235
Deposited By: S.N.Shahira Dahari
Deposited On:25 Jul 2011 07:07
Last Modified:25 Jul 2011 07:07

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