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Penicillin G solubilisation into AOT reverse micelles

Mohd. Setapar, S. H. and Wakeman, R. J. and Tarleton, E. S. (2009) Penicillin G solubilisation into AOT reverse micelles. Chemical Engineering Research and Design, 87 (6). pp. 833-842. ISSN 02638762

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Official URL: http://dx.doi.org/10.1016/j.cherd.2008.11.001


Extraction of penicillin G from an aqueous phase into an organic phase containing ACT reverse micelles has been investigated. The extraction is influenced by the initial penicillin G concentration, the salt type and concentration in the aqueous phase, pH, and surfactant concentration. The results show that penicillin is an interfacially active compound that interacts with ACT, with the interfacial association being dependent on both pH and surfactant concentration. When the concentration ratio [P](aq)/[S] is high precipitation of the penicillin occurs. The distribution coefficient favours transfer of the penicillin into the reverse micelles at moderate ACT concentrations. The distribution coefficient at infinite dilution, K(infinity), is shown to be a function of both pH and surfactant concentration; similar trends in the value of K(infinity) were observed at different pH values; K(infinity) decreases as the surfactant concentration is increased. Reverse micelle formation affects the volume of water transferred into the organic phase; from measurements of the water transferred, the size of the reverse micelles was estimated to be about 3 nm and the number of ACT molecules per reverse micelle about 360. (C) 2008 The Institution of Chemical Engineers.

Item Type:Article
Uncontrolled Keywords:anionic surfactant, extraction, partition coefficient, penicillin, reverse micelle, solubilisation, water content
Subjects:T Technology > TP Chemical technology
ID Code:13216
Deposited By: S.N.Shahira Dahari
Deposited On:21 Jul 2011 06:08
Last Modified:25 Oct 2017 06:58

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