Universiti Teknologi Malaysia Institutional Repository

Antiplatelet aggregation activity of compounds isolated from guttiferae species in human whole blood

Idris, Muhammad Sum and Jantan, Ibrahim and Mohd. Yasin, Yusyila Harlina and Jalil, Juriyati and Murad, Shahnaz (2009) Antiplatelet aggregation activity of compounds isolated from guttiferae species in human whole blood. Pharmaceutical Biology, 47 (11). pp. 1090-195. ISSN 13880209

Full text not available from this repository.

Official URL: http://dx.doi.org/10.3109/13880200903008641

Abstract

Twenty compounds isolated from Calophyllum inophyllum L., C. inophylloides King, Garcinia opaca King, G. bancana Miq., and G. parvifolia Miq. (Guttiferae) were evaluated for their ability to inhibit platelet aggregation in human whole blood induced by arachidonic acid (AA), collagen, and adenosine diphosphate (ADP). The compounds inhibited platelet aggregation in a dose-dependent manner. Among the compounds tested, 2-(3-methylbut-2-enyl)-1,3,5-trihydroxyxanthone and 2-(3-methylbut-2-enyl)-1,3,5,6- tetrahydroxyxanthone showed strong inhibitory activity on platelet aggregation induced by AA with IC50 values of 115.9 and 113.0µM, respectively. Rubraxanthone showed inhibitory activity against aggregation caused by the three inducers, and was the most effective antiplatelet compound against collagen-induced platelet aggregation with an IC50 value of 47.0µM. Macluraxanthone, GB-1a, pyranoamentoflavone, and a neoflavonoid showed selective inhibitory activity on platelet aggregation induced by ADP.

Item Type:Article
Uncontrolled Keywords:antiplatelet aggregation, Guttiferae, human whole blood
Subjects:Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Divisions:Science
ID Code:13160
Deposited By: Ms Zalinda Shuratman
Deposited On:20 Jul 2011 09:20
Last Modified:20 Jul 2011 09:20

Repository Staff Only: item control page