Mohd. Yusof, Alias and Buang, Nor Aziah and Yean, Lee Sze and Ibrahim, Mohd. Lokman (2009) The use of multi-walled carbon nanotubes as possible carrier in drug delivery system for aspirin. In: AIP Conference Proceedings. American Institute of Physics, USA, 390 -394. ISBN 978-073540673-5
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Official URL: http://dx.doi.org/10.1063/1.3160171
Carbon nanotubes (CNTs) have raised great interest in a number of applications, including field emission, energy storage, molecular electronics, sensors, biochips and drug delivery systems. This is due to their remarkable mechanical properties, chemical stability and biofunctionalizability. This nanomaterial is low in weight, has high strength and a high aspect ratio (long length compared to a small diameter). This paper will present a brief overview of drugs adsorbed onto the surface of carbon nanotubes via sonication method. The surface area of carbon nanotubes was measured by methylene blue method, Carbon nanotubes synthesized by catalytic chemical vapor deposition (CCVD) method were purified and functionalized in a mixture of concentrated acids (H2SO4: HNO3 = 3:1) at room temperature (25°C) via sonication in water bath, yielding carboxylic acid group on the CNTs' surface. CNT was successfully loaded with 48 %(w/w) aspirin molecules by suspending CNTs in a solution of aspirin in alcohol. Analysis of loaded CNTs by Field Emission-Scanning Electron Microscope (FESEM), Fourier Transform Infrared Spectrum (FITR) and UV-visible Spectroscopy confirmed the loading of the drug onto the CNTs. The work presented is a prelude to the direction of using carbon nanotubes as a drug delivery system to desired sites in human body.
|Item Type:||Book Section|
|Additional Information:||International Conference on Nanoscience and Nanotechnology, Nano-SciTech 2008; Selangor; 18 November 2008 through 21 November 2008|
|Uncontrolled Keywords:||aspirin, carbon nanotubes, drug loading, sonication|
|Subjects:||Q Science > QD Chemistry|
|Deposited By:||Liza Porijo|
|Deposited On:||20 Jul 2011 09:46|
|Last Modified:||20 Jul 2011 09:46|
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