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Simultaneous enantioseparation of cyproconazole, bromuconazole, and diniconazole enantiomers by CD-modified MEKC

Wan Ibrahim, Wan Aini and A. Warno, Susanti and Aboul-Enein, Hassan Y. and Hermawan, Dadan and Sanagi, Mohd Marsin (2009) Simultaneous enantioseparation of cyproconazole, bromuconazole, and diniconazole enantiomers by CD-modified MEKC. Electrophoresis, 30 (11). 1976 -1982. ISSN 0173-0835

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Official URL: http://dx.doi.org/10.1002/elps.200800499

Abstract

An efficient method for the simultaneous enantioseparation of cyproconazole, bromuconazole, and diniconazole enantiomers was developed by CD-modified MEKC using a dual mixture of neutral CDs as chiral selector. Three neutral CDs namely hydroxypropylb- ß-CD, hydroxypropyl-?-CD, and ?-CD were tested as chiral selectors at different concentrations ranging from 10, 20, 30 and 40 mM, but enantiomers of the studied fungicides were not completely separated. The best dual chiral recognition mode for the simultaneous separation of cyproconazole, bromuconazole, and diniconazole enantiomers was achieved with a mixture of 27 mM hydroxypropyl-ß-CD and 3mM hydroxypropyl-?-CD in 25 mM phosphate buffer (pH 3.0) containing 40 mM SDS to which methanol-acetonitrile (10%:5% v/v) was added as organic modifiers. The best separation was based on the appearance of 10 peaks simultaneously, with good resolution (Rs 1.1-15.9), and peak efficiency (N>200 000). Good repeatabilities in the migration time, peak area, and peak height were obtained in terms of RSD ranging from (0.72 to 1.06)%, (0.39 to 3.49)%, and (1.90 to 4.84)%, respectively.

Item Type:Article
Uncontrolled Keywords:CD-modified MEKC, chiral triazole fungicides, dual CD, enantioseparation
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:13105
Deposited By: Mrs Liza Porijo
Deposited On:18 Jul 2011 07:40
Last Modified:18 Jul 2011 07:40

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