Monosodium glutamate influence on cellulose acetate hemodialysis membranes

Abstract

The influence of monosodium glutamate (MSG) additive and its concentration on the performance of hemodialysis membrane were investigated. Concentration of MSG was varied from 1wt% to 8wt% and the performance of the hemodialysis membrane was evaluated in terms of urea clearance and bovine serum albumin (BSA) rejection. Results revealed that membrane with 6wt% of MSG, which was fabricated from 64wt% formic acid and 10wt% distilled water, achieved the best urea clearance of 53.20% and BSA rejection of 94%. SEM images illustrated that the increment of MSG concentration in the casting solution tends to promote macrovoids formation. However, when the amount of MSG was further increased beyond 6wt%, the urea clearance was reduced and the macrovoids structure disappeared. FTIR spectra indicated that both N-H and C-N bonds from MSG were absent indicating that the MSG was removed during phase inversion.