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Modeling of oscillatory bursting activity of pancreatic beta-cells under regulated glucose stimulation

Chew, Yin Hoon and Shia, Yoke Lin and Lee, Chew Tin and Abdul Majid, Fadzilah Adibah and Chua, Lee Suan and Sarmidi, Mohamad Roji and Abdul Aziz, Ramlan (2009) Modeling of oscillatory bursting activity of pancreatic beta-cells under regulated glucose stimulation. Molecular and Cellular Endocrinology, 307 (1-2). 57 -67. ISSN 0303-7207

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Official URL: http://dx.doi.org/10.1016/j.mce.2009.03.005

Abstract

A mathematical model to describe the oscillatory bursting activity of pancreatic beta-cells is combined with a model of glucose regulation system in this work to study the bursting pattern under regulated extracellular glucose stimulation. The bursting electrical activity in beta-cells is crucial for the release of insulin, which acts to regulate the blood glucose level. Different types of bursting pattern have been observed experimentally in glucose-stimulated islets both in vivo and in vitro, and the variations in these patterns have been linked to changes in glucose level. The combined model in this study enables us to have a deeper understanding on the regime change of bursting pattern when glucose level changes due to hormonal regulation, especially in the postprandial state. This is especially important as the oscillatory components of electrical activity play significant physiological roles in insulin secretion and some components have been found to be lost in type 2 diabetic patients.

Item Type:Article
Uncontrolled Keywords:diabetes, electrical activity, glucose regulation, oscillatory bursting, pulsatile insulin secretion
Subjects:Q Science > Q Science (General)
Divisions:Chemical and Natural Resources Engineering (Formerly known)
ID Code:12973
Deposited By: Liza Porijo
Deposited On:08 Jul 2011 01:28
Last Modified:08 Jul 2011 01:28

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