Emrizal, Emrizal and Ahmad, Farediah and Sirat, Hasnah M. and Jamaludin, Fadzureena and Mustapha, Nik Musa'adah and Ali, Rasadah M. and Arbain, Dayar (2008) Anti-inflammatory activity of piper magnibaccum (piperaceae). Natural Product Communication, 3 (10). pp. 1719-1721. ISSN 1934-578X
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Anti-inflammatory activity of a crude extract of Piper magnibaccum (Piperaceae) and of compounds isolated from it was established using the TPA-induced mouse ear edema model and an in vitro quantitative lipoxygenase inhibition assay. Five compounds were isolated from P. magnibaccum [beta-sitosterol, N-isobutyl-(2E,4E)-tetradecadienamide, linoleic acid, 13-(4', 5'-dimethoxytridecanoyl)piperidine, and piperine]. The light petroleum extract of the plant exhibited significant anti-inflammatory activity in both models. N-isobutyl-(2E,4E)-tetradecadienamide showed significant activity, with an IE % value of 70.2 +/- 5.4 in the TPA-induced mouse ear edema model and 87.2 +/- 0.11 in the in vitro quantitative lipoxygenase inhibition assay.
|Uncontrolled Keywords:||sterol, amide, TPA, lipoxygenase, anti-inflammatory activity|
|Subjects:||Q Science > QD Chemistry|
|Deposited By:||Liza Porijo|
|Deposited On:||30 Jun 2011 05:05|
|Last Modified:||30 Jun 2011 05:05|
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