Universiti Teknologi Malaysia Institutional Repository

Anti-inflammatory activity of piper magnibaccum (piperaceae)

Emrizal, Emrizal and Ahmad, Farediah and Sirat, Hasnah M. and Jamaludin, Fadzureena and Mustapha, Nik Musa'adah and Ali, Rasadah M. and Arbain, Dayar (2008) Anti-inflammatory activity of piper magnibaccum (piperaceae). Natural Product Communication, 3 (10). pp. 1719-1721. ISSN 1934-578X

Full text not available from this repository.

Abstract

Anti-inflammatory activity of a crude extract of Piper magnibaccum (Piperaceae) and of compounds isolated from it was established using the TPA-induced mouse ear edema model and an in vitro quantitative lipoxygenase inhibition assay. Five compounds were isolated from P. magnibaccum [beta-sitosterol, N-isobutyl-(2E,4E)-tetradecadienamide, linoleic acid, 13-(4', 5'-dimethoxytridecanoyl)piperidine, and piperine]. The light petroleum extract of the plant exhibited significant anti-inflammatory activity in both models. N-isobutyl-(2E,4E)-tetradecadienamide showed significant activity, with an IE % value of 70.2 +/- 5.4 in the TPA-induced mouse ear edema model and 87.2 +/- 0.11 in the in vitro quantitative lipoxygenase inhibition assay.

Item Type:Article
Uncontrolled Keywords:sterol, amide, TPA, lipoxygenase, anti-inflammatory activity
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:12809
Deposited By: Liza Porijo
Deposited On:30 Jun 2011 05:05
Last Modified:30 Jun 2011 05:05

Repository Staff Only: item control page