Mat Ali, Rasadah and Ahmad, Farediah and Wong, C. L. and Ong, B. K. (2005) Anti-inflammatory activity of extracts and compounds from Vitex negundo. Journal of Tropical Forest Science, 17 . pp. 481-487. ISSN 01281283
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Abstract
The anti inflammatory activity of the leaf extract of Vitex negundo was investigated on topical administration using the TPA. (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. The crude methanolic extract of V. negundo showed moderate inhibition (74%) at a dose of 2 mg per ear. The methanol extract was then subjected to liquid-liquid fractionation with petroleum ether, chloroform, ethyl-acetate and ethanol. Bioassay-guided chromatographic fractionation of these fractions led to the isolation of 3,4-dihydroxybenzoic acid as the bioactive principle responsible for the anti-inflammatory activity. The structures of the pure compounds were elucidated using various spectroscopic techniques.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 3,4-dihydrobenzoic acid, 4-hydroxybenzoic acid, luteolin, negundoside, verbenaceae |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| ID Code: | 12758 |
| Deposited By: | S.N.Shahira Dahari |
| Deposited On: | 28 Jun 2011 09:12 |
| Last Modified: | 25 Oct 2017 05:59 |
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