Wan Ibrahim, Wan Aini and Hermawan, Dadan and Hasan, Mohamed Noor and Aboul Enein, Hassan Y. and Sanagi, M. Marsin (2008) Rapid estimation of octanol-water partition coefficient for triazole fungicides by MEKC with sodium deoxycholate as surfactant. Chromatographia, 68 (5-9). 415 -419. ISSN 0009-5893
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Official URL: http://dx.doi.org/10.1365/s10337-008-0721-4
A rapid estimation of octanol-water partition coefficient (log P-ow) was developed for triazole fungicides by micellar electrokinetic chromatography (MEKC). Five standard compounds with known log P-ow values from 2.9 to 4.3 (cyproconazole, bromuconazole, epoxiconazole, bitertanol and difenoconazole) were used for constructing the calibration curve of the log P-ow against the MEKC retention factor, log k. A linear relationship was achieved between log P-ow and log k, in the MEKC system containing 40 mM sodium deoxycholate (SDC) and 4 mM borate buffer at pH 9.3, with a correlation of determination, r(2) = 0.9905. The log P-ow values of four test compounds of triazole fungicides (triadimenol, myclobutanil, propiconazole and penconazole) were calculated based on the log k values measured by MEKC and the slope and intercept of the calibration curve. This MEKC method can give good estimation of the log P-ow of the four test compounds of triazole fungicides with the differences between the literature log P-ow values and estimated log P-ow from the MEKC method were from 0.15 to 0.23 log units.
|Uncontrolled Keywords:||micellar electrokinetic chromatography, octanol-water partition coefficient, retention factor, triazole fungicides, bile salts|
|Subjects:||Q Science > QD Chemistry|
|Deposited By:||Liza Porijo|
|Deposited On:||27 Jun 2011 01:58|
|Last Modified:||27 Jun 2011 01:58|
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