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Anti-inflammatory activity of extracts and compounds from Vitex negundo

Rasadah, Mat Ali and Farediah, A. and Wong, C. L. and Ong, B. K. (2005) Anti-inflammatory activity of extracts and compounds from Vitex negundo. Journal of Tropical Forest Science, 17 . pp. 481-487. ISSN 01281283

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Abstract

he anti inflammatory activity of the leaf extract of Vitex negundo was investigated on topical administration using the TPA. (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. The crude methanolic extract of V. negundo showed moderate inhibition (74%) at a dose of 2 mg per ear. The methanol extract was then subjected to liquid-liquid fractionation with petroleum ether, chloroform, ethyl-acetate and ethanol. Bioassay-guided chromatographic fractionation of these fractions led to the isolation of 3,4-dihydroxybenzoic acid as the bioactive principle responsible for the anti-inflammatory activity. The structures of the pure compounds were elucidated using various spectroscopic techniques.

Item Type:Article
Uncontrolled Keywords:3,4-dihydrobenzoic acid, 4-hydroxybenzoic acid, luteolin, negundoside, verbenaceae
Subjects:Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions:Science
ID Code:12595
Deposited By: S.N.Shahira Dahari
Deposited On:14 Jun 2011 08:30
Last Modified:14 Jun 2011 08:31

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