Saaid, M. F. M. and Ibrahim, Zuwairie and Khalid, Marzuki and Sarmin, Nor Haniza and Rose, John A. (2008) Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system. In: Proceedings of the SICE Annual Conference. Society of Instrument And Control Engineers, Japan, 676 -681. ISBN 978-490776429-6
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Official URL: http://dx.doi.org/10.1109/SICE.2008.4654741
In the previous work, a readout approach for the Hamiltonian Path Problem (HPP) in DNA computing, based on the real-time polymerase chain reaction (PCR) was proposed. Based on this approach, real-time amplification was performed with TaqMan probes, and the TaqMan detection mechanism was exploited for the design and development of the readout approach. The readout approach consists of two steps: real-time amplification in vitro using TaqMan-based real-time PCR followed by information processing in silico to assess the results of real-time amplification, which in turn, enables extraction of the Hamiltonian path. However, the previous method used manual classification of two different output reactions of real-time PCR In this paper, the Fuzzy C-Means (FCM) clustering algorithm is used to automatically identify two different reactions in real-time PCR We show that the FCM clustering technique can be implemented for clustering the output results of the DNA computing readout method based on the LightCycler System.
|Item Type:||Book Section|
|Additional Information:||ISBN: 978-490776429-6; SICE Annual Conference 2008 - International Conference on Instrumentation, Control and Information Technology; Tokyo; 20 August 2008 through 22 August 2008|
|Uncontrolled Keywords:||DNA computing, fuzzy C-means, real-time PCR, taqman probes|
|Subjects:||Q Science > Q Science (General)|
Q Science > QA Mathematics
|Deposited By:||Liza Porijo|
|Deposited On:||09 Jun 2011 08:07|
|Last Modified:||09 Jun 2011 08:07|
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