Universiti Teknologi Malaysia Institutional Repository

Evaluation of the insulinotrophic activity of Malaysian traditional plants extract

Hamid, Muhajir and Mohd. Bohari, Siti Pauliena and Bastami, Mohd. Saufi and Ali, Abdul Manaf and Mustapha, Nik Musa’ adah and Shari, Khozirah (2008) Evaluation of the insulinotrophic activity of Malaysian traditional plants extract. Journal of Biological Sciences, 8 (1). 201 -204. ISSN 1727-3048

[img]
Preview
PDF
110kB

Official URL: http://dx.doi.org/10.3923/jbs.2008.201.204

Abstract

In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic ß-cell lines, BRIN-BD11 cells. In 30 min acute static incubation test, all 14 plants showed varying degree of responsiveness in insulin release with Labisa pumila, Morinda citrifolia, Momordica charantia and Tinospora crispa having high insulinotrophic activities. These plants also displayed appreciably low cytotoxic activities. These results show a promising avenue for development of novel insulin secretagogues.

Item Type:Article
Uncontrolled Keywords:insulinotrophic, Malaysian traditional plants, rat pancreatic ß-cell lines
Subjects:Q Science > Q Science (General)
Divisions:Science
ID Code:12560
Deposited By: Liza Porijo
Deposited On:09 Jun 2011 08:23
Last Modified:25 Oct 2017 04:24

Repository Staff Only: item control page