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Evaluation of the insulinotrophic activity of Malaysian traditional plants extract

Hamid, Muhajir H. A. and Bohari, Sharizal P. M. and Bastami, Mohd Saufi and Ali, Abdul Manaf and Mustapha, Noordin Mohamed and Shari, Khozirah (2008) Evaluation of the insulinotrophic activity of Malaysian traditional plants extract. Journal of Biological Sciences , 8 (1). 201 -204. ISSN 1727-3048

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Official URL: http://dx.doi.org/10.3923/jbs.2008.201.204


In this study, methanolic extracts of 14 traditional plants in Malaysia were screened for insulinotrophic properties, using rat pancreatic ß-cell lines, BRIN-BD11 cells. In 30 min acute static incubation test, all 14 plants showed varying degree of responsiveness in insulin release with Labisa pumila, Morinda citrifolia, Momordica charantia and Tinospora crispa having high insulinotrophic activities. These plants also displayed appreciably low cytotoxic activities. These results show a promising avenue for development of novel insulin secretagogues.

Item Type:Article
Uncontrolled Keywords:insulinotrophic, Malaysian traditional plants, rat pancreatic ß-cell lines
Subjects:Q Science > Q Science (General)
ID Code:12560
Deposited By: Liza Porijo
Deposited On:09 Jun 2011 08:23
Last Modified:09 Jun 2011 08:23

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