A review on rosmarinic acid rich extract for skin regeneration through rapamycin signaling pathway

Abstract

Rosmarinic acid is a phenolic compound procured from the species of the Boraginaceae and the Lamiaceae subfamily Nepetoideae. Rosmarinic acid has numeral of biologically stimulating properties. Rosmarinic acid is a chemical constituent which is a major compound found in Orthosiphon aristatus leaves and it is about 5-10% w/w in the ethanolic extract of the leaves. The skin is the largest organ of a human body and it is frequently impacted by a variety of environmental conditions, such as skin infections, skin oxidation, wounds, UV radiation exposure and skin aging. In both physiological and pathological conditions, the phosphatidylinositol 3-kinase (PI3K) / protein kinase B (AKT) enzyme aids in the preservation and repair of the epidermis, dermis, and hair follicles layer of the skin. PI3K/Akt manages cell proliferation, differentiation, migration as well as angiogenesis and metabolism. This review paper compiles, summarizes and considers on skin regenerative and wound healing.