Mohamad Amin, Mohamad Amin and Khikmawati, Nanda Hilda and Suryadi, Suryadi and Rifcha Fachrunnisa, Rifcha Fachrunnisa and Amin, Ihya Fakhrurizal and Dina Maulina, Dina Maulina and Amin, Ahya Zhilalikbar and Nik Malek, Nik Ahmad Nizam and Restu Fitriani, Restu Fitriani (2023) In silico analysis of tetrahydroxycurcumin compound in tumeric (curcuma longa) as inhibitor of SARS-CoV-2 virus replication. In: 2nd International Conference on Condensed Matters and Advanced Materials, IC2MAM 2020, 27 October 2020, Malang, Indonesia - Virtual.
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Official URL: http://dx.doi.org/10.1063/5.0139303
Abstract
There are many uses of natural ingredients to find out their potential in overcoming Coronavirus Disease 2019. One of the plants that is often used to treat various diseases, including SARS-Cov2 infection is turmeric. Turmeric contains Tetrahydroxycurcumin compounds. The aim of this research was to study the potential of Tetrahydroxycurcumin in preventing infection with the SARS-CoV-2 virus. The results showed that Tetrahydroxicurcumin has the potential to inhibit Tyrosine protein kinase ABL1, which is a protein that plays a role in the preparation of the cytoskeleton during viral infection. The binding affinity of Tetrahydroxycurcumin for this protein is -8.4 kcal/mol.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | Chemical bonding, Cytoskeleton, Diseases and conditions, Coronaviruses, Amino acid, Proteins, Viruses. |
| Subjects: | Q Science > Q Science (General) Q Science > QR Microbiology |
| Divisions: | Biosciences and Bioengineering |
| ID Code: | 107367 |
| Deposited By: | Muhamad Idham Sulong |
| Deposited On: | 03 Sep 2024 06:28 |
| Last Modified: | 03 Sep 2024 06:28 |
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