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Visible-light-driven photocatalytic dual-layer hollow fibre membrane ameliorates the changes of bisphenol A exposure in gastrointestinal tract

Kamaludin, Roziana and Othman, Mohd. Hafiz Dzarfan and Sheikh Abdul Kadir, Siti Hamimah and Khan, Jesmine and Ismail, Ahmad Fauzi and A. Rahman, Mukhlis and Jaafar, Juhana (2023) Visible-light-driven photocatalytic dual-layer hollow fibre membrane ameliorates the changes of bisphenol A exposure in gastrointestinal tract. Environmental Science and Pollution Research, 30 (1). pp. 259-273. ISSN 0944-1344

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Official URL: http://dx.doi.org/10.1007/s11356-022-22121-w

Abstract

Various treatments of choice are available to overcome contamination of bisphenol A (BPA) in the environment including membrane technologies, however, the treatment still releases contaminants that threaten the human being. Therefore, the present study is conducted to investigate the degradation of BPA by recently developed visible-light-driven photocatalytic nitrogen-doping titanium dioxide (N-doped TiO2) dual-layer hollow fibre (DLHF) membrane and its efficiency in reducing the level of BPA in contaminated water. Fabricated with suitable polymer/photocatalyst (15/7.5 wt.%) via co-extrusion spinning method, the DLHF was characterized morphologically, evaluated for BPA degradation by using submerged photocatalytic membrane reactor under visible light irradiations followed by the investigation of intermediates formed. BPA exposure effects were accessed by immunohistochemistry staining of gastrointestinal sample obtained from animal model. BPA has been successfully degraded up to 72.5% with 2 intermediate products, B1 and B2, being identified followed by total degradation of BPA. BPA exposure leads to the high-intensity IHC staining of Claudin family which indicated the disruption of small intestinal barrier (SIB) integrity. Low IHC staining intensity of Claudin family in treated BPA group demonstrated that reducing the level of BPA by N-doped TiO2 DLHF is capable of protecting the important component of SIB. Altogether, the fabricated photocatalytic DLHF membrane is expected to have an outstanding potential in removing BPA and its health effect for household water treatment to fulfil the public focus on the safety of their household water and their need to consume clean water.

Item Type:Article
Uncontrolled Keywords:BPA, Claudins, Gastrointestinal, N-doped TiO2, Photocatalytic membrane, Small intestine
Subjects:T Technology > TP Chemical technology
Divisions:Chemical and Energy Engineering
ID Code:106857
Deposited By: Widya Wahid
Deposited On:01 Aug 2024 05:38
Last Modified:01 Aug 2024 05:38

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