Suleiman, Mustapha and Almalki, Faisal A. and Hadda, Taibi Ben and Kawsar, Sarkar M. A. and Chander, Subhash and Murugesan, Sankaranarayanan and Bhat, Ajmal R. and Bogoyavlenskiy, Andrey and Jamalis, Joazaizulfazli (2023) Recent progress in synthesis, POM analyses and SAR of coumarin-hybrids as potential anti-HIV agents-a mini review. Pharmaceuticals, 16 (11). pp. 1-29. ISSN 1424-8247
![]() |
PDF
1MB |
Official URL: http://dx.doi.org/10.3390/ph16111538
Abstract
The human immunodeficiency virus (HIV) is the primary cause of acquired immune deficiency syndrome (AIDS), one of the deadliest pandemic diseases. Various mechanisms and procedures have been pursued to synthesise several anti-HIV agents, but due to the severe side effects and multidrug resistance spawning from the treatment of HIV/AIDS using highly active retroviral therapy (HAART), it has become imperative to design and synthesise novel anti-HIV agents. Literature has shown that natural sources, particularly the plant kingdom, can release important metabolites that have several biological, mechanistic and structural representations similar to chemically synthesised compounds. Certainly, compounds from natural and ethnomedicinal sources have proven to be effective in the management of HIV/AIDS with low toxicity, fewer side effects and affordability. From plants, fungi and bacteria, coumarin can be obtained, which is a secondary metabolite and is well known for its actions in different stages of the HIV replication cycle: protease, integrase and reverse transcriptase (RT) inhibition, cell membrane fusion and viral host attachment. These, among other reasons, are why coumarin moieties will be the basis of a good building block for the development of potent anti-HIV agents. This review aims to outline the synthetic pathways, structure–activity relationship (SAR) and POM analyses of coumarin hybrids with anti-HIV activity, detailing articles published between 2000 and 2023.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | AIDS, coumarin, HAART, HIV, POM, reverse transcriptase, synthesis |
Subjects: | Q Science > QD Chemistry |
Divisions: | Science |
ID Code: | 106209 |
Deposited By: | Yanti Mohd Shah |
Deposited On: | 20 Jun 2024 02:07 |
Last Modified: | 20 Jun 2024 02:07 |
Repository Staff Only: item control page