Frequency of PML-RARA and CBFB-MYH11 in Iraqi patients with acute myeloid leukemia

Abstract

Leukemia is a type of cancer that can be extremely aggressive, developing quickly and wreaking havoc on the body. This happens when genetic defects cause blood cell-producing cells in the bone marrow to divide uncontrollably. Because leukemia is heavily influenced by genetics, understanding the genetic material rearrangements that because cancer is key to improving treatment strategies. That's where this study comes in: by using advanced techniques like nested PCR and flow cytometry, researchers aimed to determine the frequency of two common fusion genes, PML-RARA and CBFB-MYH11, in Iraqi patients with acute myeloid leukemia. The results were striking, with PML-RARA showing a frequency of 10.00% and CBFB-MYH11 following closely behind with 5.71%. This groundbreaking research sheds light on the type of leukemia affecting Iraqi patients and could help pave the way for new and improved treatment options.