Hui, Yin Tey and Breadmore, Michael C. and Hong, Heng See (2023) Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe. Analytical Chemistry, 95 (4). pp. 2134-2139. ISSN 0003-2700
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Official URL: http://dx.doi.org/10.1021/acs.analchem.2c02937
Abstract
A polymer inclusion membrane (PIM) based sampling probe was developed for electrokinetic extraction of drugs from biological fluids. The probe was fabricated by dip-coating a nonconductive glass capillary tube in a homogeneous PIM solution for three cycles. The PIM solution comprised cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), and 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIM][NTf2] in a ratio of 5:4:2. The developed probe electrokinetically extracted doxorubicin from human plasma, human serum, and dried blood spot (DBS). The practicability and reliability of the electrokinetic extraction were evaluated by LC-MS/MS to quantify the desorption of extracted doxorubicin. Under the optimized conditions, a quantification limit of 0.2-2 ng/mL was achieved for the three biological samples. The probe was further integrated into a portable battery-powered device for safe low-voltage (36 V) electrokinetic extraction. The developed technique is envisioned to provide a more efficient analytical workflow in the laboratory.
Item Type: | Article |
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Uncontrolled Keywords: | cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), dried blood spot (DBS) |
Subjects: | Q Science > QD Chemistry |
Divisions: | Science |
ID Code: | 105011 |
Deposited By: | Widya Wahid |
Deposited On: | 01 Apr 2024 07:45 |
Last Modified: | 01 Apr 2024 07:45 |
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