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Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe

Hui, Yin Tey and Breadmore, Michael C. and Hong, Heng See (2023) Electrokinetic extraction of doxorubicin from biological fluids by polymer inclusion membrane sampling probe. Analytical Chemistry, 95 (4). pp. 2134-2139. ISSN 0003-2700

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Official URL: http://dx.doi.org/10.1021/acs.analchem.2c02937

Abstract

A polymer inclusion membrane (PIM) based sampling probe was developed for electrokinetic extraction of drugs from biological fluids. The probe was fabricated by dip-coating a nonconductive glass capillary tube in a homogeneous PIM solution for three cycles. The PIM solution comprised cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), and 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide [EMIM][NTf2] in a ratio of 5:4:2. The developed probe electrokinetically extracted doxorubicin from human plasma, human serum, and dried blood spot (DBS). The practicability and reliability of the electrokinetic extraction were evaluated by LC-MS/MS to quantify the desorption of extracted doxorubicin. Under the optimized conditions, a quantification limit of 0.2-2 ng/mL was achieved for the three biological samples. The probe was further integrated into a portable battery-powered device for safe low-voltage (36 V) electrokinetic extraction. The developed technique is envisioned to provide a more efficient analytical workflow in the laboratory.

Item Type:Article
Uncontrolled Keywords:cellulose triacetate (CTA), 2-nitrophenyl octyl ether (NPOE), dried blood spot (DBS)
Subjects:Q Science > QD Chemistry
Divisions:Science
ID Code:105011
Deposited By: Widya Wahid
Deposited On:01 Apr 2024 07:45
Last Modified:01 Apr 2024 07:45

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