Mani, Mohan Prasath and Mohd. Faudzi, Ahmad Athif and Mohamaddan, Shahrol and Ismail, Ahmad Fauzi and Rathanasamy, Rajasekar and Ayyar, Manikandan and Jaganathan, Saravana Kumar (2022) Grapefruit oil and cobalt nitrate-loaded polyurethane hybrid nanofibrous scaffold for biomedical applications. Frontiers in Materials, 9 (NA). pp. 1-9. ISSN 2296-8016
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Official URL: http://dx.doi.org/10.3389/fmats.2022.827009
Abstract
The goal of this work is to fabricate a new composite based on polyurethane (PU), grapefruit (GP) oil, and cobalt nitrate [Co(NO3)2] using an electrospinning technique. Morphology results revealed the reduction in the fiber diameter of the composites compared to pristine PU control. The interaction of PU with GP and Co(NO3)2 was confirmed by hydrogen bond formation evident in infrared analysis. The fabricated PU/GP composites depicted a more hydrophobic behavior, while PU/GP/Co(NO3)2 showed a hydrophilic behavior than the pristine PU. Atomic force micrographs (AFM) revealed that the developed composites showed a decrease in the surface roughness (Ra) compared to PU. The addition of GP and Co(NO3)2 improved the mechanical strength of the pristine PU. The blood compatibility assays concluded not only the increase in blood clotting levels but also the less toxic nature of the fabricated composites compared to the pristine PU. Hence, the newly designed composites possessing outstanding physicochemical and biological properties may be used as a potential candidate for scaffolding in tissue engineering applications.
Item Type: | Article |
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Uncontrolled Keywords: | Co(NO3)2, electrospun scaffold, grapefruit oil, PU, tissue engineering |
Subjects: | T Technology > TK Electrical engineering. Electronics Nuclear engineering |
Divisions: | Electrical Engineering |
ID Code: | 104047 |
Deposited By: | Widya Wahid |
Deposited On: | 14 Jan 2024 00:53 |
Last Modified: | 14 Jan 2024 00:53 |
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