In vitro antioxidant and anticholinesterase activities of ethanolic turmeric crude extract

Abstract

This study was aimed at exploring the antioxidant and anticholinesterase effect of ethanolic turmeric crude extract. The antioxidant activity was determined by using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging activity, (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) (ABTS) and ferric reducing antioxidant power (FRAP) values. Ethanolic crude extract of turmeric showed good antioxidant and anticholinesterase activities (% I), the activity was, 80.2±1.30%, 75.6±1.23% and 10.43±0.28% for ABTS, DPPH and FRAP, respectively, and 69.0±1.85% and 70.5±1.11% for AChE and BChE, respectively. However, the maximum% I for ABTS, DPPH and FRAP, that is, 87.2±1.34%, 86.0±1.59% and 19.36±0.37 µg FSE, respectively, were shown by positive control ascorbic acid, and for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition, 86.69±1.24 and 89.3±1.01%, respectively, by galanthamine. Turmeric provides a potential natural source of bioactive compounds and is valuable to human health.