Biogenic synthesis of silver nanoparticle using Cissus quadrangularis extract and its invitro study

Abstract

Objective: Green synthesis of metallic and metal oxide nanomaterial has received significant importance in various fields. Green synthesis of silver nanoparticles was performed using aqueous extracts of Cissus quadrangularis. Aqueous extracts of plants plays a major role to reduce the silver nitrate to silver nanoparticles and also aid as surface stabilizing material for silver nanoparticles production. Methods: The synthesized nanoparticles was monitored by physicochemical techniques such as XRD, FT-IR, Uv–Vis, and SEM. Anti-arthritic activity of silver nanoparticles was examined by Egg albumin denaturation and albumin (BSA) denaturation method. Results: XRD, FT-IR and Uv–Vis spectrum confirms crystalline nature of silver nanoparticles. SEM images show the spherical shape of the nanoparticles. Egg albumin denaturation method results revealed 81% inhibition and bovine serum albumin method shows 85% inhibition than standard drug. Conclusion: It confirms that, the green synthesized silver nanoparticles would be useful in promoting research aiming at the development of new agent for arthritis applications. Hence, the utilization of natural harmless materials like plant extracts for nanoparticles synthesis offers various advantages like eco-friendliness and compatibility for drug and biomedical applications.